Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-03-13
2007-03-13
Huff, Sheela J. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S388800, C530S388850, C530S391100, C530S391700, C424S133100, C424S141100, C424S155100, C424S156100, C424S181100, C435S007230, C435S069600, C435S070210
Reexamination Certificate
active
10012271
ABSTRACT:
A monoclonal antibody which recognizes an antigen of a molecular weight of 40 kD or 80 kD on the surface of tumor vessel endothelial cells, hybridomas producing the monoclonal antibody, pharmaceutical agents comprising the monoclonal antibody, as well as pharmaceutical or diagnostic agents comprising a conjugate of the monoclonal antibody and another conjugating molecule.
REFERENCES:
patent: 5489525 (1996-02-01), Pastan
patent: 5530101 (1996-06-01), Queen et al.
patent: 5951982 (1999-09-01), Zoller et al.
patent: WO-94/12631 (1994-06-01), None
patent: WO-95/33771 (1995-12-01), None
William E. Paul. Fundamental Immunology, Ch 8, pp. 242, 1993.
Taniguchi et al. International Journal of Cancer, 86(6):799-805, 2000.
Harlow et al. Antibodies, A Laboratory Manual, Chapter 5, pp. 141-142, 1988.
Ohe et al. British Journal of Cancer, 67:939-944, 1993.
Chiba et al., Cancer Research (1987) 47:1815-1819.
Connolly et al., Journal of Clinical Investigation (1989) 84(5):1470-1478.
Duerst et al., Exp. Hematol. (1991) 19:863-867.
Farr et al., J. Exp. Med. (1992) 176:1477-1482.
Iyer et al., Exp. Hematol. (1990) 18:384-389.
Kasai et al., JNCI (1981) 67(2):417-422.
Minami et al., Int. J. Cancer (1979) 23:358-365.
Ohizumi et al., Biochemical and Biophysical Research Communications (1997) 236:493-496.
Supplementary European Search Report for EP 97 90 2678, mailed on Oct. 28, 2004, 6 pages.
Taniguchi et al., Biochemical and Biophysical Research Communications (2000) 269:671-675.
Tsunoda et al., British Journal of Cancer (1999) 81(7):1155-1161.
Utoguchi et al., Jpn. J. Cancer Res. (1995) 86:193-201.
Wetterwald et al., Bone (1996) 18(2):125-132.
Brooks, et al. “Antiintegrin ανβ3 Blocks Human Breast Cancer Growth and Angiogenesis in Human Skin” J. Clin. Invest. 96:1815-1822 (1995).
Bruland, et al. “Expression and Characteristics of a Novel Human Osteosarcoma-Associated Cell Surface Antigen” Cancer Res. 48:5302-5309 (1988).
Burrows, et al. “Eradication of Large Solid Tumors in Mice with an Immunotoxin Directed Against Tumor Vasculature” Proc. Natl. Acad. Sci. USA 90:8996-9000 (1993).
Clark, et al. “The Identification of Proliferation and Tumour-induced Proteins in Human Endothelial Cells: A Possible Target for Tumour Therapy” Electrophoresis 12:500-508 (1991).
Duzhang, et al. “Generation of Monoclonal Antibodies Directed Against Organ-Specific Endothelial Cell Surface Determinants” J. Histochem. Cytochem. 39(8):1137-1142, (1991).
Fox, et al. “CD44 and Cancer Screening” The Lancet 342:548-549, (1993).
Mark, et al. “The Identification of Proliferation and Tumour-Induced Proteins in Human Endothelial Cells: A Possible Target for Tumour Therapy” Electrophoresis 12:500-508 (1991).
Naoki, et al. “Isolation and Properties of Tumor-Derived Endothelial Cells from Rat KMT-17 Fibrosarcoma” Jpn. J. Cancer Res. 86:193-201 (1995).
Rettig, et al. “Identification of Endosialin, A Cell Surface Glycoprotein of Vascular Endothelial Cells in Human Cancer” Proc. Natl. Sci. USA 89:10832-10836 (1992).
Wang, et al. Int. “A Monoclonal Antibody Detects Heterogeneity in Vascular Endothelium of Tumours and Normal Tissues” J. Cancer 54:363-370 (1993).
Wettrwald, et al. “Characterization and Cloning of the E11 Antigen, a Marker Expressed by Rat Osteoblasts and Osteocytes” Bone 18(2):125-132 (1996).
Osteoblasts and Osteocytes Bone 18(2):125-132 (1996).
Mayumi Tadanori
Nakagawa Shinsaku
Ohizumi Iwao
Tsutsumi Yasuo
Blanchard David J.
Chugai Seiyaku Kabushiki Kaisha
Huff Sheela J.
Morrison & Foerster / LLP
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