Ring fused pyrazole derivatives as CRF antagonists

Details Ring fused pyrazole derivatives as CRF antagonists Ring fused pyrazole derivatives as CRF antagonists

2007-09-11

2007-09-11

Seaman, Margaret D. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S119000

Reexamination Certificate

active

11348036

ABSTRACT:
This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II:wherein Ar is optionally substituted aryl or heteroaryl, R1-R4are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts thereof. The invention further relates to processes for preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for their use as therapeutic agents.

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Mohareb, et al., “Reactions with 4-Phenyl-3-thiosemicarbazide: A New Approach for the Synthesis of Pyrazole, Thiazole, Pyridine and Pyrazolo[3,4-b]-Pyridine Derivatives,”Sulfur Letters, (1991), pp. 101-113, vol. 13 (3).

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