DNA polymorphisms in sterol regulator element binding proteins

Details DNA polymorphisms in sterol regulator element binding proteins DNA polymorphisms in sterol regulator element binding proteins

2007-05-22

2007-05-22

Fredman, Jeffrey (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C536S022100, C536S024300, C536S024310, C536S024330

Reexamination Certificate

active

10030504

ABSTRACT:
The invention relates to DNA polymorphisms in sterol regulator element binding proteins (SREBP) that are characteristic of a higher risk of genetic diseases in humans such as hyperchlolesterolemia. The corresponding polymorphisms, especially the polymorphisms on SREBP-1 and SREBP-2 are frequently observed in Alzheimer patients (SREBP-2). They are also characterized by a specific behavior in the therapy of HIV patients with proteas inhibitors and appear to have an influence on the mortality.

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