Compounds active in spinigosine 1-phosphate signaling

Details Compounds active in spinigosine 1-phosphate signaling Compounds active in spinigosine 1-phosphate signaling

Filed on

2007-07-10

Date issued

2007-07-10

Examiner

McKane, Joseph K. (Department: 1626)

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

C548S112000, C548S340100

Type

Reexamination Certificate

Status

active

Patent number

10523337

Description

ABSTRACT:
The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure of Formula (I) wherein R11is C5–C18alkyl or C5–C18alkenyl; Q is selected from the group consisting of C3–C6optionally substituted cycloalkyl, C3–C6optionally substituted heterocyclic, C3–C6optionally substituted aryl C3–C6optionally substituted heteroaryl and —NH(CO)—; R2is selected from the group consisting of H, C1–C4alkyl, (C1–C4alkyl)OH and (C1–C4alkyl)NH2; R23is H or C1–C4alkyl, and R15is selected from the group consisting of hydroxy, phosphonate, and of Formula (II) wherein X and R15is selected from the group consisting of O and S; or a pharmaceutically acceptable salt or tautomer thereof

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