Plant enzymes for bioconversion

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process...

Reexamination Certificate

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C560S249000, C424S736000, C424S773000, C424S725000

Reexamination Certificate

active

10489762

ABSTRACT:
The invention provides a method for converting sesquiterpene. The method includes reacting a sesquiterpene substract with a sesquiterpene converting enzyme. The enzyme is from a species or organism containing sesquiterpenes. The sesquiterpene substrate is not naturally present in the species or organism.

REFERENCES:
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patent: 6451576 (2002-09-01), Croteau et al.
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Yoder OC et al. 2001. Curr Opin Plant Biol 4: 315-321.
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Bohlmann, Jorg, et al., “Plant terpenoid synthases: Molecular biology and phylogenetic analysis”,Proc. Natl. Acad. Sci.1998, 95:4126-4133.
de Kraker, Jan-Willem, et al., “Biosynthesis of Germacrene A Carboxylic Acid in Chicory Roots. Demonstration of a Cytochrome P450 (+)-Germacrene A Hydroxylase and NADP+-Dependent Sesquiterpenoid Dehydrogenase(s) Involved in Sesquiterpene Lactone Biosynthesis”,Plant Physiology2001, 125:1930-1940.
de Kraker, Jan-Willem, et al., “Germacrenes from fresh costus roots”,Phytochemistry2001, 58:481-487.
de Kraker, Jan-Willem, et al., “(+)-Germacrene A Biosynthesis”,Plant Physiol.1998, 117:1381-1392.
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