Thia-and oxazoles and their use as ppars activators

Details Thia-and oxazoles and their use as ppars activators Thia-and oxazoles and their use as ppars activators

2007-03-27

2007-03-27

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S203000, C548S204000, C548S235000, C548S236000, C514S374000

Reexamination Certificate

active

10451307

ABSTRACT:
A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof. R1and R2are independently H or C1-3alkyl, m is 0–3; X1is NH, NCH3, O, S; R3, R4and R5are independently H, CH3, CF3, OCH3, allyl or halogen; X2is (CR10R11)n wherein n is 1 or 2; R10and R11independently represent H, fluorine or C1-16alkyl; R26and R27are independently H, C1-3alkyl or R26and R27together with the carbon atom to which they are bonded form a 3–5 membered cycloalklyl ring. R6and R7independently represent H, fluorine or C1-16alkyl; R9is C1-6alkyl or CF3; One of Y and Z is N, the other is S or O; Each R8independently represents CF3, OCH3, CH3or halogen; y is O, 1, 2, 3, 4, 5. Use of a compound of formula (I) for the manufacture of a medicament for the prevention or treatment of a hPPAR mediated disease or condition, such as dyslipidemia, syndrome X, heart failure, hypercholesteremia, cardiovascular disease, type II diabetes mellitus, type 1 diabetes, insulin resistance hyperlipidemia, obesity, anorexia bulimia, inflammation and anorexia nervosa

REFERENCES:
patent: 6518290 (2003-02-01), Sierra
patent: 6710063 (2004-03-01), Chao et al.
patent: 6723740 (2004-04-01), Chao et al.
patent: 0 930 299 (1999-07-01), None
patent: 01/00603 (2001-01-01), None
patent: 01/16120 (2001-03-01), None
patent: 02/14291 (2002-02-01), None
patent: 02/059098 (2002-08-01), None
patent: 02/062774 (2002-08-01), None
Shinkai, H. et al., “Isoxazolindine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents,”Journal of Medicinal Chemistry, vol. 41, No. 11, pp. 1927-1933, May 21, 1998.
Bright, S.W., et al., “Competitive Particle Concentration Fluorescence Immunoassays for Measuring Anti-diabetic Drug Levels in Mouse Plasma,”Journal of Immunological Methods, vol. 207, No. 1, pp. 23-31, Aug. 22, 1997.

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