Process for producing D-serine

Details Process for producing D-serine Process for producing D-serine

2007-03-06

2007-03-06

Achutamurthy, Ponnathapu (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

C435S106000, C435S325000, C435S232000, C435S320100, C435S252330, C536S023200

Reexamination Certificate

active

10415107

ABSTRACT:
The present invention relates to: a process for producing D-serine wherein a microbial cell which is modified to have a higher L-serine deaminase activity thanEscherichia coliDH5α strain, a culture of said cell, or a processed product thereof is brought into contact with DL-serine in a DL-serine-containing medium to decompose L-serine, and the remaining D-serine is recovered from the medium; and a microorganism used for this production process. D-serine is a useful compound as a synthetic intermediate for useful medicaments such as D-cycloserine.

REFERENCES:
patent: 5-091895 (1993-04-01), None
patent: 98/14602 (1998-04-01), None
Witkowski et al., Biochemistry 38:11643-11650, 1999.
Broun et al., Science 282:1315-1317, 1998.
Seffernick et al., J. Bacteriol. 183(8):2405-2410, 2001.
Hongsheng Su et al., “L-Serine Degradation inEscherichia coliK-12: Cloning and Sequencing of thesdaAGene”, Journal of Bacteriology, vol. 171, No. 9, pp. 5095-5102, (1989).
ZhongQi Shao et al., “Sequencing and Characterization of thesdaBGene fromEscherichia coliK-12”, Eur. J. Biochem., vol. 212, pp. 777-784 (1993).
E.B. Newman et al., “In Vitro and In Vivo Activation of L-Serine Deaminase inEscherichia coliK-12”, Journal of Bacteriology, vol. 162, No. 3, pp. 1270-1275 (1985).
Frederic R. Bloom et al., “Positive Control in the D-Serine Deaminase System ofEscherichia coliK-12”, Journal of Bacteriology, vol. 121, No. 3, pp. 1092-1101 (1975).
English language abstract of JP 5-091895.
Shao et al., “Sequencing and characterization of the sdaB gene fromEscherichia coliK-12”, European Journal of Biochemistry, vol. 212, No. 3, pp. 777-784 (1993).

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