Cinnamoylpiperidinobutyrophenone antipsychotic agents

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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Details

542438, 546207, 546225, C07D21170, C07D40506, A61K 31445

Patent

active

042846366

ABSTRACT:
Cinnamoylpiperidinobutyrophenone derivatives and pharmaceutically acceptable salts thereof of the following general structure: ##STR1## wherein R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl; and R' is hydrogen or halogen; are useful as antipsychotic agents. The novel compounds are produced by aldol condensation of a benzaldehyde with a protected 4-(4-acetyl-1-piperidino)-butyrophenone.

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patent: 3816433 (1974-06-01), Hernestam et al.
patent: 4101662 (1978-07-01), Ward et al.
Krauch et al., Organic Name Reactions, John Wiley & Sons, N.Y., N.Y., 1964, p. 6-9.

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