Method for improving oxygen transport by stored red blood cells

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell

Reexamination Certificate

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C424S533000, C514S006900

Reexamination Certificate

active

10967475

ABSTRACT:
A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solution can be administered to the patient prior to administrating the stored red blood cells or the stored red blood cells can be administered to the patient prior to administering the hemoglobin solution. A composition of the invention includes stored red blood cells and a hemoglobin solution.

REFERENCES:
patent: 5618919 (1997-04-01), Rausch et al.
patent: 5865784 (1999-02-01), Faithfull et al.
Gueye et al., “Influence of human haptoglobin polymorphism on oxidative stress induced by free hemoglobin on red blood cells”, Clinical Chemistry and Laboratory Medicine 44 (5) : 542-547 (2006), abstract.
Chang, T.M.S., “The Use of Modified Hemoglobin as an Oxygen Carrying Blood Substitute,”Transfusion Medicine Reviews, 3(3):213-218 (1989).
Homer, L.D. et al., “Oxygen Gradients between Red Blood Cells in the Microcirculation1,”Hypoxia Between Red Cells, pp. 308-323 (1981).
Lovric, V.A., “Alterations in Blood Components during Storage and their Clinical Significance,”Anaesthesia and Intensive Care, 12(3):246-251 (1984).
Marik, P.E. et al., “Effect of Stored-Blood Transfusion on Oxygen Delivery in Patients With Sepsis,”JAMA, 269(23):3024-3029 (1993).
Masouredis, S.P., “Preservation and clinical use of erythrocytes and whole blood,” InHematology, Williams et al., eds. (NY: McGraw Hill), pp. 1529-1549 (1983).
Oudemans-van Straaten, H.M. et al., “Analysis of P50and oxygen transport in patients after cardiac surgery,”Intensive Care Med., 22:781-789 (1996).
Page, T.C. et al., “Oxygen Transport by Erythrocyte/Hemoglobin Solution Mixtures in an in Vitro Capillary as a Model of Hemoglobin-Based Oxygen Carrier Performance,”Microvascular Research, 55:54-64 (1998).
Page, T.C. et al., “Prediction of Microcirculatory Oxygen Transport by Erythocyte/Hemoglobin Solution Mixtures,”Microvascular Research, 56:113-126 (1998).
Page, T.C. et al., “Experimental and Mathematical Simulation of Oxygen Transport by Hemoglobin-based Blood Substitute,” InBlood Substitutes—Present and Future Perspectives, E. Tsuchida, ed. pp. 135-145 (1998).
Page, T.C. et al., “Oxygen Transport In 10μm Artificial Capillaries,” InOxygen Transport to Tissue XXI, Eke et al., eds. (NY: Kluwer Academic/Plenum Publishers), pp. 715-721 (1999).
Page, T.C. et al., “Experimental and Theoretical Simulation of Oxygen Transport with Erythocytes and Extracellular Hemoglobin-Based Materials,” Presented at ISBS VI, Montreal, Quebec, Canada (Aug. 1996).
Page, T.C. et al., “Experimental and Theoretical Simulation of Oxygen Transport with Erythrocytes and Extracellular Hemoglobin Solutions,” Presented at Biomedical Engineering Society, Fall Meeting, Boston, Massachusetts (1995).
Page, T.C. et al., “Experimental Determination of Intraluminal Oxygen Transport by Hemoglobin Based Oxygen Transport by Hemoglobin Based Oxygen Carriers In 10 μm Capillaries,” Presented at ISOTT, Budapest, Hungry (1998).
Page, T.C. et al., “Experimental Simulation of Oxygen Transport in 10 μm Capillaries,” Presented at ISOTT, Milwaukee (1997).
Page, T.C. et al., “In Vitro model of Microcirculatory Oxygen Transport,” Presented at the BMES, Fall Meeting, Tempe, Arizona (1994).
Parris, W.C.W. et al., “The effect of intentional hemodilution on P50,”J. Cardiovasc. Surg., 29:560-562 (1988).
Standl, T. et al., “Hemodynamics and Oxygen Transport During Complete Isovolemic Hemodilution with a New Ultrapurified Poly-Merized Bovine Hemoglobin Solution in a Dog Model,” Paper presented at the Annual Meeting of the American Society of Anesthesiologists in Washington, (1993).
Sugerman, H.J. et al., “The Basis of Defective Oxygen Delivery From Stored Blood,”Surgery, Gynecology&Obstetrics, pp. 733-741 (1970).
Tsai, A.G. et al., “Local Tissue Oxygenation during Constant Red Blood Cell Flux: A Discrete Source Analysis of Velocity and Hematocrit Changes1,”Microvascular Research, 37:308-322 (1989).
Uehira, A., et al., “Oxygen affinity measurement of preserved blood,”Vox Sanguinis, 70(suppl. 2), (1996).
Valeri, C.R. et al., “Physiologic Effects of Transfusing Red Blood Cells with High Low Affinity for Oxygen to Passively Hyperventalated Anemic Baboons,”Ann. Surg., 181(1):106-113 (1974).
Valeri, C.R. et al., “Therapeutic Effectiveness and Safety of Outdated Human Red Blood Cells Rejuvenated to Improve Oxygen Transport Function, Frozen for About 1.5 Years at 80 C, Washed, and Stored at 4 C for 24 Hours Prior to Rapid Infusion,”Transfusion, 20(3):263-276 (1980).
Wells, R.M.G. et al., “Changes of Blood Oxygen Affinity in Different CPD Solutions during Liquid Storage,”Transfusion, 21(6):709-714 (1981).
Standl, T. et al., “Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution in dogs,”Can J Anaesth 43(7): 714-23 (1996).
LaMuraglia, G.M. et al., “The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution,”J. Vascular Surgery 31(2):299-308 (Feb. 2000).
Slanetz, P.J. et al., “Hemoglobin blood substitutes in extended preoperative autologous blood donation: An experimental study,”Surgery 115(2):246-254 (Feb. 1994).

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