Preparation of vaccines using a photosensitizer and light

Details Preparation of vaccines using a photosensitizer and light Preparation of vaccines using a photosensitizer and light

2007-03-06

2007-03-06

Chen, Stacy B. (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

C435S004000, C435S005000

Reexamination Certificate

active

10325402

ABSTRACT:
Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.

REFERENCES:
patent: 3259546 (1966-07-01), Polley
patent: 4402318 (1983-09-01), Swartz
patent: 4545987 (1985-10-01), Giles et al.
patent: 4556556 (1985-12-01), Wiesehahn et al.
patent: 4693981 (1987-09-01), Wiesehahn et al.
patent: 4915683 (1990-04-01), Sieber
patent: 4960408 (1990-10-01), Klainer et al.
patent: 5106619 (1992-04-01), Wiesehahn et al.
patent: 5143717 (1992-09-01), Davis
patent: 5571666 (1996-11-01), Floyd et al.
patent: 5686436 (1997-11-01), Van Dyke
patent: 5846961 (1998-12-01), Van Dyke
patent: 6165711 (2000-12-01), Dorner et al.
patent: 6258577 (2001-07-01), Goodrich et al.
patent: 6268120 (2001-07-01), Platz et al.
patent: 2004/0005712 (2004-01-01), Platz
patent: 2004/0006028 (2004-01-01), Platz
patent: 2004/0038373 (2004-02-01), Platz et al.
patent: 0124363 (1984-11-01), None
patent: 0196515 (1986-10-01), None
patent: WO03/054150 (2003-07-01), None
patent: WO03/095621 (2003-11-01), None
patent: WO2004/043338 (2004-05-01), None
Eertweigh et al, Adjuvant treatment of colorectal cancer: Towards tumor-specific immunotherapies,Cancer and Metastasis Reviews, 20:101-108, 2001.
Vermorken et al, “Active specific immunotherapy for stage II and stage III human colon cancer: a randomized trial”,The Lancet, 353:345-50, 1999.
Baars et al, A phase II study of active specific immunotherapy and 5-FU/Leucovorin as adjuvant therapy for stage III colon carcinoma,British Journal of Cancer, 86(8):1230-1234, 2002.
International Search Report for corresponding foreign application: PCT/US02/40923.
Balladur, Helene, “Photolysis of Riboflavin Induces Apoptosis in Epstein-Barr Virus Transformed Lymphoblastoid Cells: Design of a Cellular Vaccine for EBV-Associate Lymphoma”, Masters Thesis, Ohio State University, 2002, pp. 57-65.
Dardare et al, “Binding Affinities of Commonly Employed Sensitizers of Viral Inactivation”,Photochemistry and Photobiology, 2002, 75(6): 561-564.
Wagner et al, “Determination of Residual 4′-aminomethyl-4,5′,8-trimethylpsoralen and Mutagenicity Testing following Psoralen Plus UVA Treatment of Platelet Suspensions”,Photochemistry and Photobiology, vol. 57, No. 5, pp. 819-824, 1993.
International Search Report for corresponding foreign application: PCT/US02/40923 (2003).

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