Sodium channel blockers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S242000, C514S252110, C514S255050, C544S238000, C544S295000, C544S357000

Reexamination Certificate

active

10828329

ABSTRACT:
The present invention relates to compounds represented by formula (I):in which at least one of R3and R4is a group represented by formula (A):where the structural variables are defined herein. The compounds are useful for blocking sodium channels.

REFERENCES:
patent: 3313813 (1967-04-01), Cragoe, Jr. et al.
patent: 3472848 (1969-10-01), Cragoe, Jr. et al.
patent: 3539569 (1970-11-01), Pollack et al.
patent: 3544571 (1970-12-01), Cragoe, Jr. et al.
patent: 3573306 (1971-03-01), Shepard et al.
patent: 3625950 (1971-12-01), Cragoe, Jr.
patent: 3668241 (1972-06-01), Cragoe, Jr. et al.
patent: 3794734 (1974-02-01), Cragoe, Jr. et al.
patent: 3864401 (1975-02-01), Schultz et al.
patent: 3894065 (1975-07-01), Cragoe, Jr. et al.
patent: 3914253 (1975-10-01), Cragoe, Jr. et al.
patent: 3928624 (1975-12-01), Cragoe, Jr. et al.
patent: 3929872 (1975-12-01), Cragoe, Jr. et al.
patent: 3931239 (1976-01-01), Cragoe, Jr. et al.
patent: 3953476 (1976-04-01), Cragoe, Jr. et al.
patent: 3956374 (1976-05-01), Shepard et al.
patent: 3958004 (1976-05-01), Cragoe, Jr. et al.
patent: 3966966 (1976-06-01), Cragoe, Jr. et al.
patent: 3974212 (1976-08-01), Cragoe, Jr. et al.
patent: 3976681 (1976-08-01), Cragoe, Jr. et al.
patent: 3976686 (1976-08-01), Cragoe, Jr. et al.
patent: 3979361 (1976-09-01), Schultz et al.
patent: 3984465 (1976-10-01), Cragoe, Jr. et al.
patent: 3984552 (1976-10-01), Cragoe, Jr. et al.
patent: 3987091 (1976-10-01), Cragoe, Jr. et al.
patent: 3989749 (1976-11-01), Cragoe, Jr. et al.
patent: 3991087 (1976-11-01), Cragoe, Jr. et al.
patent: 3991106 (1976-11-01), Cragoe, Jr. et al.
patent: 4003927 (1977-01-01), Woltersdorf, Jr. et al.
patent: 4006180 (1977-02-01), Cragoe, Jr. et al.
patent: 4012524 (1977-03-01), Cragoe, Jr. et al.
patent: 4025625 (1977-05-01), Rooney et al.
patent: 4067980 (1978-01-01), Cragoe, Jr. et al.
patent: 4085117 (1978-04-01), Cragoe, Jr. et al.
patent: 4085211 (1978-04-01), Cragoe, Jr. et al.
patent: 4085219 (1978-04-01), Cragoe, Jr. et al.
patent: 4087526 (1978-05-01), Cragoe, Jr. et al.
patent: 4087542 (1978-05-01), Cragoe, Jr. et al.
patent: 4092414 (1978-05-01), Cragoe, Jr. et al.
patent: 4100294 (1978-07-01), Cragoe, Jr. et al.
patent: 4105769 (1978-08-01), Rooney et al.
patent: 4140776 (1979-02-01), Cragoe, Jr. et al.
patent: 4145551 (1979-03-01), Cragoe, Jr. et al.
patent: 4159279 (1979-06-01), Smith et al.
patent: 4163781 (1979-08-01), Cragoe, Jr. et al.
patent: 4163794 (1979-08-01), Cragoe, Jr. et al.
patent: 4177285 (1979-12-01), Cragoe, Jr. et al.
patent: 4181727 (1980-01-01), Cragoe, Jr. et al.
patent: 4196292 (1980-04-01), Woltersdorf, Jr. et al.
patent: 4237130 (1980-12-01), Cragoe, Jr. et al.
patent: 4237144 (1980-12-01), Cragoe, Jr. et al.
patent: 4246406 (1981-01-01), Cragoe, Jr. et al.
patent: 4277602 (1981-07-01), Woltersdorf et al.
patent: 4291050 (1981-09-01), Woltersdorf, Jr. et al.
patent: 4296122 (1981-10-01), Cragoe, Jr. et al.
patent: 4298743 (1981-11-01), Cragoe, Jr. et al.
patent: 4317822 (1982-03-01), Woltersdorf, Jr. et al.
patent: 4362724 (1982-12-01), Bock et al.
patent: 4401669 (1983-08-01), Cragoe, Jr. et al.
patent: 6475509 (2002-11-01), Boucher, Jr.
patent: WO 01/05773 (2001-01-01), None
Velly et al, “Effects of amiloride and its analogues on [3H]batrachotoxinin-A 20-α benzoate binding, [3H]tetracaine binding and 22 Na influx” European Journal of Pharmacology, vol. 149, No. 1-2, 1988, pp. 97-105.
Kellerman, D. “P2Y2 Receptor Agonists. A New Class of Medication Targeted at Improved Mucociliary Clearance” Chest, vol. 121(5), supplement, pp. 201S-205S.
R. Tarran et al., The CF Salt Controversy: In Vivo Observations and Therapeutic Approaches,Molecular Cell, vol. 8, 149-158, Jul. 2001.
Michael R. Knowles et al.,Amiloride in Cystic Fibrosis: Safety, Pharmacokinetics, and Efficacy in the Treatment of Pulmonary Disease, Chapter 20, p. 301-316, 1992.
Louis Simchowitz et al.,An Overview of the Structure Activity Relations in the Amiloride Series, Chapter 2, p. 9-25, 1992.
J.R. Sabater et al., Aerosolization of P2v2-Receptor Agonists Enhances Mucociliary Clearance in Sheep,The American Physiological Society, p. 2191-2196, 1999.
Thomas R. Kleyman et al., Amiloride and Its Analogs as Tools in the Study of Ion Transport,The Journal of Membrane Biology, vol. 105, pp. 1-21, 1988.
Edward C. Taylor et al., A Facile Route to “Open Chain” Analogues of DDATHF,Heterocycles, vol. 28, No. 2, 1989.
Paul-Michael Windscheif et al., Substituted Dipyridlethenes and—ethynes and Key Pyridine Building Blocks,Synthesis, pp. 87-92, Jan. 1994.
Edward J. Cragoe, Jr.,The Synthesis of Amiloride and Its Analogs, p. 24-38, Chapter 3, 1992.
Jack H. Li, et al., Stereoselective Blockage of Amphibian Epithelial Sodium Channels by Amiloride Analogs,The Journal of Pharmacology and Experimental Therapeutics, vol. 267, No. 3, pp. 1081-1084, 1993.
Pallav L. Shah, M.D.,Chapter 7, Progress in the Treatment of Pulmonary Disease in Cystic Fibrosis, Annual Reports in Medicinal Chemistry, vol. 36, pp. 67-76, 2001.
Dieter Worlitzsch et al., Effects of Reduced Mucus Oxygen Concentration in Airway Pseudomonas Infections of Cystic Fibrosis Patients,The Journal of Clinical Investigation, Feb. 2002, vol. 109, No. 3, pp. 317-336.
Edward J. Cragoe, Jr., et al., Chapter 7: Diuretic Agents,Annual Reports in Medicinal Chemistry, 1966, p. 59-68.
Edward J. Cragoe, Jr., et al., Chapter 7: Diuretic Agents,Annual Reports in Medicinal Chemistry, 1965, p. 67-77.
Robert L. Smith, et al., Chapter 8: Diuretics,Annual Reports in Medicinal Chemistry, vol. 11, pp. 71-79, 1976.
Robert L. Smith, et al., Chapter 7: Diuretics,Annual Reports in Medicinal Chemistry, vol. 13, pp. 61-70, 1978.
Edward J. Cragoe, Jr., Structure-Activity Relationships in the Amiloride Series,Merck Sharp and Dohme Research Laboratories, 1979, pp. 1-20.
T.M. Cocks, et al., British Journal of Pharmacology, 95(1), pp. 67-76 (English) 1988.
Thomas R. Kleyman, et al., American Journal of Physiology, 260(2, Pt. 1), pp. C271-C276 (English), 1991.
K.E. Barrett, et al., Annu. Rev. Physiol. 2000; 62, pp. 535-572.
R.F. Epand, et al., British Journal of Cancer, 63(2), 247-51 (English) 1991.

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