3,6-disubstituted azabicyclo [3.1.0]hexane derivatives...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S452000

Reexamination Certificate

active

10523208

ABSTRACT:
This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

REFERENCES:
patent: 3176019 (1965-03-01), Campbell et al.
patent: 4183857 (1980-01-01), Kollmeyer
patent: 5281601 (1994-01-01), Cross et al.
patent: 5948792 (1999-09-01), Tsuchiya et al.
patent: 6130232 (2000-10-01), Mase et al.
patent: 6130241 (2000-10-01), Schulz
patent: 6174900 (2001-01-01), Okada et al.
patent: 6313312 (2001-11-01), Banks et al.
patent: 0 325 571 (1989-07-01), None
patent: 0 388 054 (1990-09-01), None
patent: 0 801 067 (1997-10-01), None
patent: 940540 (1963-10-01), None
patent: 92921/1994 (1994-04-01), None
patent: 135958/1994 (1994-05-01), None
patent: WO91/09013 (1991-06-01), None
patent: WO93/16018 (1993-08-01), None
patent: WO93/16048 (1993-08-01), None
patent: WO96/33973 (1996-10-01), None
patent: WO97/45414 (1997-12-01), None
patent: WO98/05641 (1998-02-01), None
patent: WO98/29402 (1998-07-01), None
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Kubo et al., “Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor”,Nature, 323(2):411-416 (1986).
Bonner et al., “Identification of a Family of Muscarinic Acetylcholine Receptor Genes”,Science, 237:527-531 (1987).
Eglen et al., “Muscarinic receptor ligands and their theraputic potential”,Current Opinion in Chemical Biology, 3:426-432 (1999).
Eglen et al., “Theraputic opportunities from muscarinic receptor research”,Trends in Pharmacological Sciences, 22(8):409-414 (2001).
Felder et al., “Theraputic Opportunities for Muscarinic Receptors in the Central Nervous Systems”,Journal of Medicinal Chemistry, 43(23):4333-4353 (2000).
Broadley and Kelly, “Muscarinic Receptor Agonists and Antagonists”,Molecules, 6:142-193 (2001).
Birdsall et al., “Muscarinic receptors: it's a knockout”,Trends in Pharmacological Sciences, 22(5):215-219 (2001).
de Groat and Yoshimura, “Pharmacology of the Lower Urinary Tract”,Annual Review of Pharmacology and Toxicology, 41:691-721 (2001).
Steers, “The future direction of neuro-urology drug research”,Current Opinion in CPNS Investigational Drugs, 2(3):268-282.
Chapple, “Muscarinic receptor antagonists in the treatment of overactive bladder”,Urology, 55(Suppl. 5A):33-46 (2000).
Steers, Barrot, Wein, “Voiding dysfunction: diagnosis classification and management”, In:Adult and Pediatric Urology, ed. Gillenwater, Grayhack, Howards, Duckett. Mosby, St. Louis, MO; 1220-1325, 3rd edition (1996).
Sagara et al, “Cyclohexylmethylpiperidinyltriphenylpropioamide: A Selective Muscarinic M3Antagonist Discriminating against the Other Receptor Subtypes”,Journal of Medicinal Chemistry, 45(4):984-987 (2002).
Vogel's textbook, “Practical Organic Chemistry” 1046-1047 (5th Ed.).
Grover et al., “Chiral Mandelic Acid Template Provides a Highly Practical Solution for (S)-Oxybutynin Synthesis”,Journal of Organic Chemistry, 65:6283-6287 (2000).
Cheng and Prusoff, “Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction”,Biochemical Pharmacology, 22:3099-3108 (1973).
Dobson and Raphael, “729. The synthesis of DL-baikiain”,Journal of the Chemical Society, 3642-3647 (1958).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

3,6-disubstituted azabicyclo [3.1.0]hexane derivatives... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3756393

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.