Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives

Details Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives

2007-05-01

2007-05-01

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S320000

Reexamination Certificate

active

11219923

ABSTRACT:
The invention relates to a 2-(diaza-bicyclo-alkyl)-pyrimidone derivative represented by formula (I):wherein:R1 represents a hydrogen atom, a C1-6alkyl group or a halogen atom; R2 represents a hydrogen atom, a C1-6alkyl group optionally substituted by 1 to 4 substituents selected from a halogen atom, a hydroxyl group, a C1-4alkoxy group; a C1-2perhalogenated alkyl group, a benzyl group, a phenethyl group, a benzyloxycarbonyl group, a C1-4alkoxy carbonyl group, a benzene ring, a naphthalene ring, a quinoline ring, a phthalazine ring, a 5,6,7,8-tetrahydronaphthalene ring, a pyridine ring, an indole ring, a pyrrole ring, a thiophene ring, a benzenesulfonyl group, a benzoyl group, a pyridazine ring, a furan ring and an imidazole ring; each of the benzyl group, the phenethyl group, the benzyloxycarbonyl group, the benzenesulfonyl group, the benzoyl group and the benzene, naphthalene, quinoline, phthalazine, 5,6,7,8-tetrehydronaphthalene, pyridine, indole, pyrrole and thiophene rings being optionally substituted by 1 to 4 substituents selected from a C1-6alkyl group, a benzene ring, a halogen atom, a C1-2perhalogenated alkyl group, a C1-3halogenated alkyl group, a hydroxyl group, a C1-4alkoxy group, a nitro group, a cyano group, an amino group, a C1-6monoalkylamino group and a C2-10dialkylamino group; R3 represents a 2, 4 or 5-pyrimidine ring or a 2, 3 or 4-pyridine ring, the rings being optionally substituted by a C1-4alkyl group, C1-4alkoxy group or a halogen atom; R4 represents a C1-4alkyl group optionally substituted by a hydroxyl group, a C1-4alkoxy group or a halogen atom and n represents 1 or 2; or a salt thereof, or a solvate thereof or a hydrate thereof. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer's disease.

REFERENCES:
patent: 0400661 (1990-12-01), None
patent: 0841326 (1998-05-01), None
patent: 1136483 (2001-09-01), None
patent: WO 03/072579 (2003-09-01), None
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition, vol. 1, 1004-1010, 1996.
Jope et al., Trends in Biochemical Sciences, 20(2): 95-102, 2004.
Cohen et al., Nature Reviews/Molecular Biology 2: 769-776, 2001.

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