Quinazoline derivatives and drugs

Details Quinazoline derivatives and drugs Quinazoline derivatives and drugs

2007-05-22

2007-05-22

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S266100, C514S266200, C544S284000

Reexamination Certificate

active

10399803

ABSTRACT:
The invention provides an excellent novel analgesic which acts on a nociceptin receptor to exhibit a wide range of the analgesic effect for example on a chronic pain as well as an allodynia accompanied with a herpes zoster.The invention relates to a nociceptin receptor agonist comprising as an active ingredient a compound represented by Formula (I) or a salt thereof:wherein R1represents a hydrogen atom or alkyl; A1and A2are the same or different and each represents a single bond or a divalent aliphatic hydrocarbon group; Q represents a single bond, cycloalkylene group, phenylene group or a divalent heterocyclic group; R2Aand R2Bare the same or different and each represents a hydrogen atom or alkyl; R3represents an optionally substituted phenyl group or heterocyclic group; R4and R5are the same or different and each represents a hydrogen atom, alkyl, alkoxy, aralkyloxy, halogen, nitro, hydroxy, alkoxycarbonyl, —NR6R7and the like.

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