Selective estrogen receptor modulators

Details Selective estrogen receptor modulators Selective estrogen receptor modulators

2007-01-02

2007-01-02

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S222000, C549S496000, C514S471000, C514S630000, C514S647000

Reexamination Certificate

active

10486005

ABSTRACT:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

REFERENCES:
patent: 4731471 (1988-03-01), Cragoe, Jr. et al.
patent: WO 01/72713 (2001-10-01), None
patent: WO 01/82923 (2001-11-01), None
patent: WO 02/16316 (2002-02-01), None
patent: WO 02/41835 (2002-05-01), None
Database CASPLUS on STN, Acc. No. 2001:816451, Parker et al., WO 2001082923 (Nov. 8, 2001) (abstract).

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