Spiro-rifamycin derivatives targeting RNA polymerase

Details Spiro-rifamycin derivatives targeting RNA polymerase Spiro-rifamycin derivatives targeting RNA polymerase

2007-04-10

2007-04-10

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S453000, C540S457000

Reexamination Certificate

active

11147520

ABSTRACT:
Compounds of the current invention relate to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. More specifically, compounds of the current invention relate to a series of novel spiro rifamycin derivatives which have demonstrated potent antimicrobial activity.

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Farr, B. M.; “Rifamycins”; Principles and Practice of Infectious Diseases; Mandell, G. L., Bennett, J. E., Dolin, R., Eds.; Churchhill Livingstone: Philadelphia, pp. 348-361.
Marchi, E., et al; “4-Deoxypyrido[1′,2′:1,2]imidazo[5,4-c]rifamycin SV Derivatives. A new Series of Semisynthetic Rifamycins with High Antibacterial Activity and Low Gastroenteric Absorption”;, J. Med Chem, vol. 28, pp. 960-963, 1985.

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