Benzamidine derivatives having anti-inflammatory and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C514S585000, C514S623000, C514S625000, C514S419000

Reexamination Certificate

active

10467624

ABSTRACT:
Compounds which can be represented by the general formula (I) indicated below:and in which:A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group,R1is selected from an alkyl group having from 1 to 3 carbon atoms and the amino group, unsubstituted or substituted with the nitro group or the methyl group,R2is selected independently from hydrogen, an alkyl group having from 1 to 4 carbon atoms, the methoxy, ethoxy, propoxy group, a mono-, bi- or tricyclic cycloalkane residue having from 5 to 12 carbon atoms, the adamantyl group, an aryl, naphthyl or heterocyclic group, unsubstituted or substituted with methyl, methoxy, hydroxy, amino or halogen groups,R3and R4are selected independently from hydrogen and an alkyl group having from 1 to 3 carbon atoms,R5represents one or two substituents independently selected from hydrogen and the methyl, methoxyl and hydroxyl groups,n is a whole number from 0 to 6, andthe amidine group is in the para or meta position relative to the “-A-NH—” group.

REFERENCES:
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patent: 5240694 (1993-08-01), Gwaltney, Jr.
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Swallow et al, Annals New York Academy of Sciences, vol. 284, pp. 305-309, 1977.
George Cy Chiou et al.; Exp. Opin. Ther. Patents (1996), vol. 6(1), pp. 41-56, Ashley Publications Ltd. ISSN 1354-3776.
James B Summers et al.; Annual Reports in Med. Chemistry vol. 33, pp. 131-140, Academic Press 1998.

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