Preparation of new pharmaceutically suitable salt of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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10524993

ABSTRACT:
Pharmaceutically suitable crystalline and amorphous alkali and earth-alkali salts of 2-n-butyl-4-chloro-5-hidrox-ymethyl-1-[[2′-(1 H-tetrazole-5-yl)[1.1′-biphenyl]-4-yl]-1 Himidazole have been prepared and new manufacturing, purification and isolation procedure for said salts in high purity have been described. Stable pharmaceutical compositions containing new crystalline potassium salts of 2-n-butyl-5-chloro-5hidroxymethyl-1-[[2′-(1H-tetrazole-5-yl)[1.1′-biphenyl]-44-yl]-1H-imidazole have been prepared.

REFERENCES:
patent: 5795904 (1998-08-01), Cohen
patent: 5962500 (1999-10-01), Eide et al.
patent: 2004/0097568 (2004-05-01), Reddy et al.
Brittain in Polymorphism in Pharmacetical Solids (1999).
Elbary et al., “Polymorphic Transformation of Losartan”, Egypt. J. Pharm. Sci., vol. 40, No. 1, pp. 49-59 (1999).

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