Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-01-09
2007-01-09
Chism, B. Dell (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S315000
Reexamination Certificate
active
10380153
ABSTRACT:
The present invention relates to an improved method for the treatment of hypovolaemia or hypotension associated with therapeutic paracentesis, which method is characterised by the use of a peptide according to general formulae (I) or a salt thereof, wherin Asn, Cys, Gln, Gly, Phe and Pro represent the amino acid residues asparigine, cysteine, glutamine, glycine, phenylalanine and proline respectively; Phe(X) represents a phenylalanine residue optionally substituted at the 4-position of the aromatic ring by a group selected from methyl, ethyl, hydroxy and methoxy; Y represents a group —(CH2)a—NH-Q, where a is 2–5 and Q is H or C(═NH)NH2; and R represents a chain of between two and for αalpha-amino acid residues, at least one of which is glycine, as the active agent. The invention also provides uses of the peptide and pharmaceutical compositions.
REFERENCES:
Eyraud, et al., Anesth Analg. May 1999; 88(5): 980-984.
Arroyo et al., J. Hepatol. 2000, vol. 32(suppl. 1): pp. 157-170.
Zertova, M. et al., The Analogs of 8-D-Homoarginine-Vasopressin Withp-Substituted Phenylalanine in Position 2; Synthesis and Some Biological Properties, Collect. Czech. Chem. Commune.(vol. 55) 1990.
Jans, D., et al., Biotinyl Analogues of Vasopressin as Biologically Active Probes for Vasopressin Receptor Expression in Cultured Cells, The Journal of Biological chemistry, pp. 14599-14605, No. 24, 1990.
Salo, J., et al., Effect of Therapeutic Paracentesis on Plasma Volume and Transvascular Escape Rate of Albumin in Patients with Cirrhosis, Journal of Hepatology, pp. 645-653, 1997.
Møller, S., et al., Central and Systemic Haemodynamic Effects of Terlipressin in Portal Hypertensive Patients, pp. 51-59, Liver, 2000.
Lebrec Didier
Moreau Richard
Chism B. Dell
Townsend and Townsend / and Crew LLP
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