Truncated CD200

Details Truncated CD200 Truncated CD200

2007-04-17

2007-04-17

Gambel, Phillip (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

10416510

ABSTRACT:
A truncated form of the full-length, immunosuppression-inducing molecule, CD200, CD200tr, was expressed in CHO cells and the transduced cells used to produce mAbs to CD200tr. These mAbs detect simultaneous expression of full-length CD200 and CD200trin LPS-stimulated dendritic cells (DCs). Moreover, CHO cells and DCs expressing CD200tras well as soluble CD200trare able to inhibit suppression of mixed leucocyte reactions in vitro which follows addition of the soluble form of CD200 (CD200:Fc) in culture, demonstrating that CD200tris a physiological antagonist of CD200.

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