Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2007-03-27
2007-03-27
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C514S114000
Reexamination Certificate
active
09503852
ABSTRACT:
Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more acid sphingomyelinase (ASMase) gene products. Specifically, methods disclosed herein serve to protect women's germline from damage resulting from cancer therapy regimens including chemotherapy or radiotherapy. In one aspect, the method preserves, enhances, or revives ovarian function in women, by administering to women a composition containing sphingosine-1-phosphate, or an analog thereof. Also disclosed are methods to prevent or ameliorate menopausal syndromes and to improve in vitro fertilization techniques.
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Kolesnick Richard N.
Tilly Jonathan L.
Edwards Angell Palmer & & Dodge LLP
Hartley Michael G.
The General Hospital Corporation
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