Preparation of erythropoietin by endogenous gene activation

Details Preparation of erythropoietin by endogenous gene activation Preparation of erythropoietin by endogenous gene activation

2007-03-06

2007-03-06

Ketter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C536S023510

Reexamination Certificate

active

10353767

ABSTRACT:
The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.

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