Method and composition for inhibiting cancer cell growth

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S012000, C435S227000

Reexamination Certificate

active

10621833

ABSTRACT:
A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.

REFERENCES:
patent: 4837380 (1989-06-01), Deftos et al.
patent: 5411884 (1995-05-01), Hellstrom et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5750496 (1998-05-01), Forney et al.
patent: 6126938 (2000-10-01), Guy et al.
patent: 6248330 (2001-06-01), Labigne et al.
patent: 6426086 (2002-07-01), Papahadjopoulos et al.
patent: 2003/0108966 (2003-06-01), Mather
patent: WO 95/22987 (1995-08-01), None
patent: WO95/31480 (1995-11-01), None
patent: WO 98/37207 (1998-08-01), None
patent: WO 01/00245 (2001-01-01), None
Int'l. Search Report from Int'l. Appln. No. PCT/CA03/01061; Int'l. Filing Date: Jul. 16, 2003.
Bagshawe, K.D., et al., “A cytotoxic agent can be generated selectively at cancer sites,”Br. J. Cancer58 pp. 700-703 (1988).
Herron, J.N., et al., “Antibodies and targeting moieties: affinity measurements, conjugation chemistry and applications in immunoliposomes,”J. Controlled Release28:1/3 pp. 155-166 (1994).
Raghunand, N., et al., “Enhancement of chemotherapy by manipulation of tumour pH,”B. J. Cancer80:7 pp. 1005-1011 (1999).
Shi, G., et al., “Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations,”J. Controlled Release80:1-3 pp. 309-319 (2002).
Wampler, G.L., et al., “Antitumor activity of acetohydroxamic acid,”Proceedings of AACR and ASCO, Abstract18 p. 214 (1977).
Zimber, A., et al., “Effect of Urease Injections on Ehrlich Ascites Tumor Growth in Mice,”Proceedings of the Society for Experimental Biology and Medicine139:1 143-149 (1972).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and composition for inhibiting cancer cell growth does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and composition for inhibiting cancer cell growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and composition for inhibiting cancer cell growth will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3731980

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.