Pyrazole-amine compounds for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S371700, C548S365700, C548S364400

Reexamination Certificate

active

11078861

ABSTRACT:
The present invention relates to compounds of the Formulawherein R1, R3, R4, R5, R6, R7and R8are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods of treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.

REFERENCES:
patent: 43006621 (1968-03-01), None
patent: 48010069 (1973-02-01), None
patent: 0112188 (2001-02-01), None
patent: 0218346 (2002-03-01), None
patent: 0248114 (2002-06-01), None
patent: 03064396 (2003-08-01), None
patent: 03094854 (2003-11-01), None
patent: 2004033434 (2004-04-01), None
patent: 2004099200 (2004-11-01), None
patent: WO 2005009344 (2005-02-01), None
CAS Abstract attached.
Citron, M. Nature Reviews Neuroscience 2004, 5, 677-685.
Tanzi, R.E. Nature Medicine 1996, 2(1), 31-32.
Masters et al. Proc. Natl. Acad. Sci. USA 1985, 82, 4245-4249.
Lawrence D. Wise et al, Journal of Medicinal Chemistry, (5-Amino-1,3-Dimethyl-1H-Pyrazol-4-Yl)(2-Fluorophenyl) Methanones. A Series of Novel Potential Antipsychotic Agents, 1986, vol. 29, pp. 1628-1637.
XP-002346273, File Caplus, STN CA Caesar Accession No. 1145, 1968:506704 Caplus, 69:106704, p. 1-2, Pyrazole Derivatives, Kameyama, Tsutomu, et al, Takeda Chemical Industries, Ltd., Jpn. Tokyo Koho, 9 pp.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyrazole-amine compounds for the treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrazole-amine compounds for the treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazole-amine compounds for the treatment of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3729205

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.