Use of pramipexole to treat amyotrophic lateral sclerosis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

10496714

ABSTRACT:
The present invention is directed to compositions comprising pramipexole and the use of such compositions to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). As shown in FIG.6B the mean +/− SEM serum 2,3-DHBA levels for the 12 ALS participants decreased significantly after pramipexole treatment.

REFERENCES:
patent: 4731374 (1988-03-01), Griss et al.
patent: 5650420 (1997-07-01), Hall et al.
patent: 6156777 (2000-12-01), Hall et al.
patent: 6187802 (2001-02-01), Cheetham et al.
patent: WO 0113902 (2001-03-01), None
patent: WO 0122820 (2001-04-01), None
patent: WO 0162249 (2001-08-01), None
Cassarino et al., An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses and cell death in neurodegeneration., Brain Research Reviews, 29m 1999, pp. 1-25.
Hardy et al. Genetic Classification of Primary Neurodegenerative Disease, Science: Nov. 6, 1998, vol. 282 No. 5391, pp. 1075-7079.
Roberecht, Wim (2000). “Oxidative stress in amyotrophic lateral sclerosis.” J. Neurol, vol. 247, pp. 1/1-1/6.
Cassarino, David S. and Bennett, Jr., James P. (1999). “An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration.” Brain Research Reviews, vol. 29, pp. 1-25.
Swerdlow, R.H., Parks, J.K., Cassarino, D.S. Trimmer, P.A., Miller, S.W., Maguire, D.J., Sheehan, J.P., Maguire, R.S. Pattee, G., Juel, V.C. Phillips, L.H., Tuttle, J.B., Bennett, Jr., J.P., Davis, R.E. Parker, Jr., W.D. (1998). “Mitochondria in Sporadic Amyotrophic Lateral Sclerosis.” Experimental Neurology, vol. 153, pp. 135-142.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Use of pramipexole to treat amyotrophic lateral sclerosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of pramipexole to treat amyotrophic lateral sclerosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of pramipexole to treat amyotrophic lateral sclerosis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3727927

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.