Statine derivatives for the treatment of Alzheimer's disease...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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11268197

ABSTRACT:
The invention relates to a compound of the formula (I)wherein R1, R2, R3, R4, R5, R6, R7and R8are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.

REFERENCES:
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Hu et al. “Design and Synthesis of Statine-Containing BACE Inhibitors,” Bioorg. Med. Chem. Let., 2003, 13, 4335-9.
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Zuo, Z. et al: “Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase” Bioorganic & Medicinal Chemistry, Elsevier Science Ltd, GB, vol. 13, No. 6, Mar. 15, 2005; pp. 2121-2131; abstract; table 1.
Kuzmic, P., et al: “Long Range Electrostatic Effects in Pepsion Catalysis” Tetrahedron, Elsevier Science Publishers, Amsterdam, NL, vol. 47, No. 14/15, 1991 pp. 2519-2534.
Hu, Jingdan; et al: “Design and Synthesis od Statine-Containing Bace Inhibitors”, Bioorganic ans Medical Chemistry Letters 13, (2003) 43335-4339, XP 002304453.

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