Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1985-09-18
1988-01-19
Sutto, Anton H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564500, 564501, 564374, 564389, 564391, 564440, 564461, 546312, 546334, 548337, 548342, 548483, 548504, 549 68, 549 75, 549480, 549495, C07C14924, C07C14914
Patent
active
047205857
ABSTRACT:
Aminopeptidase inhibitory activity is exhibited by compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, carboxyalkyl, halo-substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl or heteroaryl; and
REFERENCES:
Pickering, D. S. et al., "Structural Requirements for Specific Inhibition of Microsomal Aminopeptidase by Mercaptoamines", Arch. Biochem. & Biophys., vol. 239, No. 2, Jun. 1985, pp. 368-374.
Godfrey Jr. Jollie D.
Gordon Eric M.
Barrack Donald J.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Sopp John A.
Sutto Anton H.
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