Aminopeptidase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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564500, 564501, 564374, 564389, 564391, 564440, 564461, 546312, 546334, 548337, 548342, 548483, 548504, 549 68, 549 75, 549480, 549495, C07C14924, C07C14914

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active

047205857

ABSTRACT:
Aminopeptidase inhibitory activity is exhibited by compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, carboxyalkyl, halo-substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl or heteroaryl; and

REFERENCES:
Pickering, D. S. et al., "Structural Requirements for Specific Inhibition of Microsomal Aminopeptidase by Mercaptoamines", Arch. Biochem. & Biophys., vol. 239, No. 2, Jun. 1985, pp. 368-374.

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