Cytochrome P450 genetic variations

Details Cytochrome P450 genetic variations Cytochrome P450 genetic variations

2007-03-27

2007-03-27

Fredman, Jeffrey (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C536S023200, C536S024330

Reexamination Certificate

active

10712363

ABSTRACT:
A primer set used to screen a polynucleotide sample to detect and identify variants in the Cytochrome P450 isoenzyme 2D6 (CYP2D6) gene. A method of screening a polynucleotide sample to detect and identify the presence of one or more than one variant in the CYP2D6 gene in the sample. A method of predicting the potential for altered metabolism of a substance, including one or more than one pharmaceutical drug, by a first individual compared to a second control individual, where the substance is metabolized by the CYP2D6 isoenzyme, and where the second control individual is homozygous for the wild type allele of the CYP2D6*1, SEQ ID NO:1. A method of screening a population to detect and identify the presence of one or more than one variant in the CYP2D6 gene. A purified or isolated variant of SEQ ID NO:1. A purified or isolated variant of SEQ ID NO:3.

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GenBank Accession No. M33388 (1994). 5 pages. Accessed Aug. 9, 2006.
Buck et al. Design strategies and performance of custom DNA sequencing primers. Biotechniques (1999) 27: 528-536.
Longo et al. Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions. Gene (1990) 93(1): 125-128.

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