N-formyl hydroxylamine compounds, compositions and methods...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S342000, C514S365000, C514S422000, C514S464000, C546S269700, C546S278400, C546S279100, C548S200000, C548S518000, C548S526000, C549S439000

Reexamination Certificate

active

07148242

ABSTRACT:
N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes or imidazacyclo4-7alkanes have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.

REFERENCES:
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4303662 (1981-12-01), Sprague
patent: 4311705 (1982-01-01), Ondetti et al.
patent: 4321383 (1982-03-01), Sprague
patent: 4599361 (1986-07-01), Dickens et al.
patent: 4804676 (1989-02-01), Inaoka et al.
patent: 5128346 (1992-07-01), Nadzan et al.
patent: 5256657 (1993-10-01), Singh et al.
patent: 5268384 (1993-12-01), Galardy
patent: 5447929 (1995-09-01), Broadhurst et al.
patent: 5453423 (1995-09-01), Long et al.
patent: 5552419 (1996-09-01), MacPherson et al.
patent: 5614625 (1997-03-01), Broadhurst et al.
patent: 5643908 (1997-07-01), Sugimura et al.
patent: 5712300 (1998-01-01), Jacobsen
patent: 5869518 (1999-02-01), Bedoya Zurita et al.
patent: 236 872 (1987-09-01), None
patent: 274 453 (1988-07-01), None
patent: 334 244 (1989-09-01), None
patent: 423 943 (1991-04-01), None
patent: 489 577 (1992-06-01), None
patent: 489 579 (1992-06-01), None
patent: 497 192 (1992-08-01), None
patent: 574 758 (1993-12-01), None
patent: WO 90/05716 (1990-05-01), None
patent: WO 90/05719 (1990-05-01), None
patent: WO 91/02716 (1991-03-01), None
patent: WO 92/13831 (1992-08-01), None
patent: WO 92/22523 (1992-12-01), None
patent: WO 93/09090 (1993-05-01), None
patent: WO 93/09097 (1993-05-01), None
patent: WO 93/20047 (1993-10-01), None
patent: WO 93/24449 (1993-12-01), None
patent: WO 93/24475 (1993-12-01), None
patent: WO 94/02446 (1994-02-01), None
patent: WO 94/02447 (1994-02-01), None
patent: WO 94/21612 (1994-09-01), None
patent: WO 94/25434 (1994-11-01), None
patent: WO 94/25435 (1994-11-01), None
patent: WO 95/33731 (1995-12-01), None
patent: WO 96/25156 (1996-08-01), None
patent: WO 96/26918 (1996-09-01), None
patent: WO 97/30707 (1997-08-01), None
patent: WO 97/49674 (1997-12-01), None
patent: WO 98/55449 (1998-12-01), None
patent: WO 99/02510 (1999-01-01), None
patent: WO 99/39704 (1999-08-01), None
patent: WO 9939704 (1999-08-01), None
Bord et al., “Stromelysin-1 (MMP-3) and Stromelysin-2 (MMP-10) Expression in Developing Human Bone: Potential Roles in Skeletal Development”, Bone, vol. 23, No. 1, pp. 7-12 (1998).
Chang et al., “Methionine Aminopeptidase Gene ofEscherichia coliIs Essential for Cell Growth”, J. Bacteriol., vol. 171, No. 7, pp. 4071-4072 (1989).
Durand et al., “Peptide Aldehyde Inhibitors of Bacterial Peptide Deformylases”, Arch. Biochem. Biophys., vol. 367, No. 2, pp. 297-302 (1999).
Gearing et al., “Processing of Tumour Necrosis Factor-α Precursor by Metalloproteinasis”,Nature, vol. 370, pp. 555-557 (1994).
Hao et al., “Structural Basis for the Design of Antibiotics Targeting Peptide Deformylase”,Biochemistry, vol. 38, No. 15, pp. 4712-4719 (1999).
Hu et al., “H-Phosphonate Derivatives as Novel Peptide Deformylase Inhibitors”,Bioorg. Med. Chem. Letts., vol. 8, pp. 2479-2482 (1998).
Izquierdo-Martin et al., “Mechanistic Studies on the Inhibition of Thermolysin by a Peptide Hydroxamic Acid”,J. Am. Chem. Soc., vol. 114, No. 1, pp. 325-331 (1992).
Liu et al., “Distinct Expression of Gelatinase A [Matrix Metalloproteinase (MMP)-2], Collagenase-3 (MMP-13), Membrane Type MMP 1 (MMP-14), and Tissue Inhibitor of MMPs Type 1 Mediated by Physiological Signals During Formation and Regression of the Rat Corpus Luteum”,Endocrinology, vol. 140, No. 11, pp. 5330-5338 (1999).
Mazel et al., Genetic Characterization of Polypeptide Deformylase, a Distinctive Enzyme of Eubacterial Translation,EMBO J., vol. 13, No. 4, pp. 914-923 (1994).
McGeehan et al., “Regulation of Tumour Necrosis Factor-a Processing by a Metalloproteinase Inhibitor”,Nature, vol. 370, pp. 558-561 (1994).
Meinnel et al., “Characterization of theThermus thermophilusLocus Encoding Peptide Deformylase and Methionyl-tRNAfMetFormyltransferase”,J. Bacteriol., vol. 176, No. 23, pp. 7387-7390 (1994).
Meinnel et al., “Structure-Function Relationships within the Peptide Deformylase Family. Evidence for a Conserved Architecture of the Active Site Involving Three Conserved Motifs and a Metal Ion”,J. Mol. Biol., vol. 267, pp. 749-761 (1997).
Meinnel et al., “Design and Synthesis of Substrate Analogue Inhibitors of Peptide Deformylase”,Biochemistry, vol. 38, No. 14, pp. 4287-4295 (1999).
Mohler et al., “Protection Against a Lethal Dose of Endotoxin by an Inhibitor of Tumour Necrosis Factor Processing”,Nature, vol. 370, pp. 218-220 (1994).
O'Connell et al., “A High Quality Nuclear Magnetic Resonance Solution Structure of Peptide Deformylase fromEscherichia coli: Application of an Automated Assignment Strategy Using GARANT”,J. Biomol. NMR, vol. 13, No. 4, pp. 311-324 (1999).
Rajagopalan et al., “Purification, Characterization, and Inhibition of Peptide Deformylase fromEscherichia coli”, Biochemistry, vol. 36, No. 45, pp. 13910-13918 (1997).
Yamagiwa et al., “Expression of Metalloproteinase-13 (Collagenase-3) Is Induced During Fracture Healing in Mice”,Bone, vol. 25, No. 2, pp. 197-203 (1999).

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