Biological contraceptive and contraceptive technique for males

Details Biological contraceptive and contraceptive technique for males Biological contraceptive and contraceptive technique for males

1984-03-05

1988-01-19

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514841, A61K 31045

Patent

active

047205075

ABSTRACT:
A male contraceptive preparation and a contraceptive technique are disclosed. The contraceptive preparation consists essentially of 1,2,3-trihydroxypropane ("THP"; glycerol) in solution in a suitable carrier such as distilled water or saline solution. In accordance with the contraceptive technique, the contraceptive preparation is injected into the testes. The THP has been found to act as a potent inhibitor of spermatogenesis, resulting in long term infertility, with no apparent effect on libido, secondary sex characters, mating behavior and hormone levels. There are no observed side effects and no observed effects on other aspects of reproductive and hormonal biology.

REFERENCES:
patent: 4156427 (1979-05-01), Fahim
patent: 4356189 (1982-10-01), Stagg et al.
Remington--Pharmaceutical Sciences, 1980, p. 1255.
Lachman et al.--The Theory & Practice of Industrial Pharmacy, 2nd Ed., 1976, pp. 586-589.
Chemical Abstracts, 77:14938p, (1972).

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