Method of inhibiting vertebrate collagenase activity using pepti

Details Method of inhibiting vertebrate collagenase activity using pepti Method of inhibiting vertebrate collagenase activity using pepti

1987-01-07

1988-01-19

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

525 541, A61K 3702, C08F28300

Patent

active

047204869

ABSTRACT:
Novel peptide hydroxamic acid derivatives having useful collagenase inhibitory activity and capable of forming affinity resins for the purification of vertebrate collagenase are defined by the following structural formula:

REFERENCES:
patent: 3931184 (1976-01-01), Lex
patent: 4138394 (1979-02-01), Sakakibara et al.
patent: 4443367 (1984-04-01), Weingarten
patent: 4466919 (1984-08-01), Weingarten
Masui et al., Biochem. Med., 17, 215-221, (1977).
Nishino and Powers, Biochem., 17, 2846, (1978).
Nishino and Powers, Biochem., 18, 4340-4347, (1979).

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