Substituted pyrimidines as selective cyclooxygenase-2...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S330000, C544S332000

Reexamination Certificate

active

07084148

ABSTRACT:
A compound of formula (I):and pharmaceutically acceptable derivatives thereof, wherein R1is H or C1-6alkyl; R2iswhereindefines the point of attachment of the ring; and R3is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of pain, fever, inflammation of a variety of conditions and diseases.

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