Method of predicting drug-food interaction

Details Method of predicting drug-food interaction Method of predicting drug-food interaction

2006-08-29

2006-08-29

Gitomer, Ralph (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C424S009100, C424S009200

Reexamination Certificate

active

07097967

ABSTRACT:
The present invention provides a method of predicting a food-drug interaction in vivo, in the case of an orally administered drug interactive with digestive enzymes in the gastrointestinal tract, by measuring the activity of the drug to the digestive enzymes in vitro, which is based on the fact that the ingestion of foods causes the absorption of drug in vivo to decrease due to the above interaction between a drug and digestive enzymes. The present invention further provides methods of minimizing the change of absorption in vivo caused by the ingestion of foods by reducing the action of digestive enzymes, for example, introduction of prodrugs, modification of the chemical structure of drug, design of drug formulation, etc.

REFERENCES:
patent: 5294615 (1994-03-01), Meyer et al.
patent: 6013680 (2000-01-01), Ogawa et al.
patent: 6338857 (2002-01-01), Seth
patent: 6368628 (2002-04-01), Seth
patent: 2002/0094346 (2002-07-01), Lin
patent: 2003/0118547 (2003-06-01), Vandenberg
patent: 2004/0229821 (2004-11-01), Kim et al.
patent: 00/39124 (2000-07-01), None
Vallez M. Different Food Interactions for the Orally Active Thrombin Inhibitors S 18326 and S 31922 In Dogs. Poster 2289 XVIIth Congress of the International Society For Thrombosis & Haemostasis, Washington, DC. 1999.
Carver, P.L., et al., “Meal Composition Effects on the Oral Bioavailability of Indinavir in HIV-Infected Patients,”Pharmaceutical Research, vol. 16, No. 5, pp. 718-724 (1999).
Charman, W.N., et al., “Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH,”Journal of Pharmaceutical Sciences, vol. 86, No. 3, pp. 269-282 (Mar. 1997).
Fleisher, D., et al., “Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration,”Clin. Pharmacokinetics, vol. 36, No. 3, pp. 233-255 (Mar. 1999).
Garty, M. and A. Hurwitz, “Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline,”Clin. Pharmacol. Ther., vol. 28, No. 2, pp. 203-207 (Aug. 1980).
Gustafsson, D., et al., “The Direct Thrombin Inhibitor Melagatran and Its Oral Prodrug H 376/95: Intestinal Absorption Properties, Biochemical and Pharmacodynamic Effects,”Thrombosis Research, vol. 101, pp. 171-181 (2001).
Hoffken, g., et al., “Pharmacokinetics and Bioavailability of Ciprofloxacin and Ofloxacin: Effect of Food and Antacid Intake,”Rev. Infect. Dis., vol. 10, pp. S138-S139 (1988).
Kane, G.C. and J.J. Lipsky, “Drug-Grapefruit Juice Interactions,”Mayo Clin Proc., vol. 75, pp. 933-942 (2000).
Luciano, V.S.,Human Physiology, 5th edition, Chapter 16, pp. 526-545 (1990).
Pao, L-H., et al., “Reduced Systemic Availability of an Antiarrhythmic Drug, Bidisomide, with Meal Co-Administration: Relationship with Region-Dependent Intestinal Absorption,”Pharmaceutical Research, vol. 15, No. 2, pp. 221-227 (1998).
Rowland, M. and T.N. Tozer,Clinical Pharmacokinetics: Concepts and Applications, Chapter 17, pp. 246-248 (1980).
Schmidt, L.E. and K. Dalhoff, “Food-Drug Interactions,”Drugs, vol. 62, No. 10, pp. 1481-1502 (2002).
Shuman, R.T. and P.D. Gesellchen, “Development of an Orally Active Tripeptide Arginal Thrombin Inhibitor,”Pharmaceutical Biotechnology, vol. 11, Integration of Pharmaceutical Discovery and Development, pp. 57-80, no date given.
Singh, B.N., “Effects of food on clinical pharmacokinetics,”Clinical Pharmacokinetics, vol. 37, No. 3, pp. 231-255 (1999).
Vallez; M-O, et al., “Different food interaction for the orally active thrombin inhibitors S 18326 and S 31922 in dogs,”Poster 2289, XVIIth Congress of the International Society for Trombosis and Haemostasis, Washington D.C. (1999).

Affiliated with

Also associated with

Rating

Method of predicting drug-food interaction does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of predicting drug-food interaction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of predicting drug-food interaction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3712529