Production method for biarylalanine

Details Production method for biarylalanine Production method for biarylalanine

2006-08-15

2006-08-15

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C562S443000

Reexamination Certificate

active

07091373

ABSTRACT:
There is provided a production method for producing a biarylalanine compound of formula (4):wherein R1represents a amino protective group and R2represents an amino protective group or a hydrogen atom, R3is a carboxy protective group, or the like, andR4is a substituted or unsubstituted aryl or heteroaryl group, characterized by reacting an aromatic amino acid of formula (1)wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R1, R2and R3has the same meaning as defined above, with an organic boron compound of formula (2):wherein R4has the same meaning as defined above, and Q1and Q2are the same or different and each is a hydroxy group, an alkoxy group having 1 to 4 carbon atom(s), in the presence of nickel catalyst and a base.

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