Substituted arylpyrazines

Details Substituted arylpyrazines Substituted arylpyrazines

2006-02-07

2006-02-07

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S252110, C514S255050, C544S120000, C544S336000, C544S357000, C544S408000, C544S409000

Reexamination Certificate

active

06995161

ABSTRACT:
Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF1receptors, including human CRF1receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF1receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.

REFERENCES:
patent: 4211870 (1980-07-01), Barnett et al.
patent: 4293552 (1981-10-01), Miesel
patent: 4788197 (1988-11-01), Wakabayashi et al.
patent: 1499768 (1978-02-01), None
patent: 3048666 (1991-03-01), None
patent: WO 95/10506 (1995-04-01), None
patent: WO 99/38829 (1998-01-01), None
patent: WO 98/11075 (1998-03-01), None
patent: WO 9838174 (1998-09-01), None
patent: WO 98/38174 (1998-09-01), None
patent: WO 98/43641 (1998-10-01), None
patent: WO 00/12488 (2000-03-01), None
patent: WO 00/45800 (2000-08-01), None
CAS printout for Miesel et al. Chem. Abs. 96: 35307, 1982.
CAS printout for Teranishi et al. (JP 10077286) 1998.
CAS printout for Hamazaki et al. Chem. Abs. 100: 5477, 1984.
CAS printout for Hori et al. Chem. Abs. 80:890, 1974.
CAS printout of Teranishi et al. Chem. Abs. 114:101506, 1991.
CAS printout of McCapra et al. Chem. Abs. 79:125387, 1973.
CAS printout of Inoue et al. Chem. Abs. 93:114448, 1980.
CAS printout for Miesel from PTO-892 issued in U.S. Appl. No. 09/576,709, filed Aug. 13, 2001.
CAS printout for Rees et al. (WO 98/43641), 1998.
CAS printout for Teranishi et al. (JP 1998-184331), 1998.
Office Action issued for U.S. Appl. No. 09/576,709, filed Aug. 13, 2001.
Amendment filed in U.S. Appl. No. 09/576,709, filed Oct. 16, 2001.
Smagin, G. et al.,Neuroscience Letters, vol. 220, 167-170, 1996.
Kalin, N.H. et al.,Brain Res., vol. 656, 182-186, 1994.
Smagin, G. et al.,Brain Res. Bull., vol. 42(6), 431-434, 1997.
Bremner, J.D. et al.,Am. J. of Psychiatry, vol. 154(5), 624-629, 1997.
Schulz, D.W. et al.,Proc. Natl. Acad. Sci. USA, vol. 93, 10477-10482, 1996.
Mitchell, A.J.,Neuroscience and Biobehavioral Reviews, vol. 22(5), 635-651, 1998.
Vinot, N. and Pinson, J.,Bulletin de la Société Chimique de France, No. 12, 4970-4974, 1968.
Badiger, R.B. et al.,Indian J. of Chem., vol. 16B, 71-75, 1978.
Alvernhe, G. et al.,Tetrahedron Letters, vol. 21, 1437-1440, 1980.
Chellappa, J. et al.,Indian J. of Chem., vol. 21B, 778-779, 1982.
Akita, Y. et al.,Chem. Pharm. Bull.34(4), 1447-1458, 1986.
Ohta, A. et al.,Heterocycles, vol. 24(3), 785-792, 1986.
Taylor, E.C. et al.,J. Org. Chem., vol. 54, 1245-1249, 1989.
Taylor, E.C. et al.,J. Org. Chem., vol. 54, 1249-1256, 1989.
Benincori, T. et al.,J. Chem. Soc. Perkin Trans., 2139-2145, 1991.
Ohta, A. et al.,Biol. Pharm. Bull., vol. 20(10), 1076-1081, 1997.
Yamagami, C. et al.,J. of Pharm. Sciences, vol. 88(12), 1299-1304, 1999.
Iredale, P.A. et al.,Mol. Pharm., vol. 50, 1103-1110, 1996.
Heinrichs, S.C. et al.,Neuropsychopharmacology, vol. 11(3), 179-186, 1994.
Menzaghi, F. et al.,J. of Pharm. And Exp. Therapeutics, vol. 269(1), 564-572, 1994.

Affiliated with

Also associated with

Rating

Substituted arylpyrazines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted arylpyrazines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted arylpyrazines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3705379