Prodrug esters of diflunisal and related compounds

Details Prodrug esters of diflunisal and related compounds Prodrug esters of diflunisal and related compounds

1982-10-25

1985-09-17

Rivers, Diana G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

260463, A61K 31265, C07C 6996

Patent

active

045421587

ABSTRACT:
1-(Alkoxy or aroxy)carbonyloxyalkyl esters of diflunisal and related compounds are stable in aqueous medium and non-irritant to mucous membranes of mouth, throat, and stomach. Accordingly, they are useful Prodrugs of the analgesic and anti-inflammatory drug, diflunisal.

REFERENCES:
patent: 3590082 (1971-06-01), Sarett et al.
patent: 3714226 (1973-01-01), Ruyle et al.
patent: 4417064 (1983-11-01), Mehta
patent: 4426391 (1984-01-01), Alexander et al.
N. O. Bodin, et al., Antimicrobial Agents and Chemotherapy, vol. 8, No. 5, pp. 518-525, (1975).

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