Detecting compounds with liquid crystals

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

Reexamination Certificate

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C422S051000, C422S068100, C422S082010, C436S004000, C436S501000, C436S524000, C436S528000, C436S805000, C427S162000, C349S199000

Reexamination Certificate

active

07135143

ABSTRACT:
A device for detecting a compound in a sample includes a substrate and a self-assembled monolayer. The substrate includes a support with a metallized top surface, and the self-assembled monolayer includes an alkanethiol attached to the metallized top surface of the substrate and having a functional group that reversibly or irreversibly interacts with the compound. A liquid crystal is disposed on the self-assembled monolayer opposite the side of the self-assembled monolayer attached to the metallized top surface of the substrate. The liquid crystal includes a moiety that interacts with the functional group of the alkanethiol. When the compound is present in a sample that that contacts the self-assembled monolayer, the orientation of the liquid crystal is altered.

REFERENCES:
patent: 5620850 (1997-04-01), Bamdad et al.
patent: 6284197 (2001-09-01), Abbott et al.
patent: 6288392 (2001-09-01), Abbott et al.
patent: WO 99/63329 (1999-12-01), None
patent: WO 99/64862 (1999-12-01), None
Fergason, J., “Liquid Crystals,”J. Sci. Amer.,vol. 211, pp. 77-83, 1964.
Fergason, J., et al., “Thermal Radiography Utilizing Liquid Crystals,”Mol. Cryst. Liq. Cryst.,vol. 13, pp. 149-164, 1971; published by Gordon and Breach Science Publishers.
Novak, T. J., et al., “Use of Anisotropic Materials as Chemical Detectors,”Analytical Letters,vol. 5, No. 3, pp. 187-192, 1972; Marcel Dekker, Inc.
Poziomek, E. J., et al., “Use of Liquid Crystals as Vapor Detectors,”Mol. Cryst. Liq. Cryst.,vol. 27, pp. 175-185, 1973; published by Gordon and Breach Science Publishers, Ltd.
Kolesar, Jr., E., “Organophosphorus Compound Detection with a Supported Copper + Cuprous Oxide Island Film. 1. Gas-Sensitive Gilm Physical characteristics and Direct Current Studies,”Anal. Chem.,vol. 60, No. 17, pp. 1731-1736, Sep. 1, 1988.
Kolesar, Jr., E., et al., “Organophosphorus Compound Detection with a Supported Copper + Cuprous Oxide island Film. 2. Alternating Current Studies and Sensor Performance,”Anal. Chem.,vol. 60, No. 17, pp. 1737-1743, Sep. 1, 1988.
Pieranski, P., et al., “Adsorption-induced anchoring transistions at nematic-liquid-crystal-crystal interfaces,”Physical Review A,vol. 40, No. 1, pp. 317-322, Jul. 1, 1989; published by The American Physical Society.
Nuzzo, R. G., et al., “Fundamental Studies of Microscopic Wetting on Organic Surfaces. 1. Formation and Structural characterization of a Self-Consistent Series of Polyfunctional Organic Monolayers,”J. Am. Chem. Soc.,vol. 112, pp. 558-569, 1990.
Bechhoefer, J., et al., “Systematic Studies of the Anchoring Transition in Nematic Liquid Crystals,”Physical Review A,vol. 41, No. 6, pp. 3187-3191, Mar. 15, 1990; published by The American Physical Society.
Pieranski, P., et al., “Adsorption-Induced Anchoring Transitions,”Mol. Cryst. Liq. Cryst.,vol. 179, pp. 285-315, 1990; published by Gordon and Breach Science Publishers S.A., printed in the United States of America.
Bechhoefer, J., et al., “Anchoring Transitions of Nematic Liquid Crystals,”Phase Trans.,vol. 33, pp. 227-236, 1991; published by Gordon and Breach Science Publishers S.A., printed in the United Kingdom.
Kepley, L. J., et al., “Selective Surface Acoustic Wave-Based Organophosphonate Chemical Sensor Employing a Self-Assembled Composite Monolayer: A New Paradigm for Sensor Design,”Anal. Chem.,vol. 64, pp. 3191-3193, Dec. 15, 1992.
Butler, M. A., et al., “Fiber Optic Micromirror Studies of the Interaction of Thin Copper Films with an Organophosphonate,”Anal. Chem.,vol. 64, No. 17, pp. 1851-1854, Sep. 1, 1992.
Milanko, O. S., et al., “Evaluation of coating materials used on piezoelectric sensors for the detection of organophosphorus compounds in the vapour phase,”Anal. Chim. Acta,vol. 269, pp. 289-300, 1992; published by Elsevier Science Publishers B.V.
Jerome, B., et al., “Anchoring of nematic liquid crystals on mica in the presence of volatile molecules,”Physical Review E,vol. 48, No. 6, pp. 4556-4574, Dec. 1993; published by The American Physical Society.
Yao, S., et al., “Circuit network analysis method applied to surface acoustic wave impedance system in liquids,”Anal. Chim. Acta,vol. 294, pp. 311-318, 1994; published by Elsevier Science Publishers B.V.
Drawhorn, R. A., et al., “Anchoring of Nematic Liquid Crystals on Self-Assembled Monolayers Formed from Alkanethiols on Semitransparent Films of Gold,”J. Phys. Chem.,vol. 99, No. 45, pp. 16511-16515, 1995.
Yang, L., et al., “Chemical Sensing Using Sol-Gel Derived Planar Waveguides and Indicator Phases,”Anal. Chem.,vol. 67, No. 8, pp. 1307-1314, Apr. 15, 1995; published by American Chemical Society.
Gupta, V. K., et al., “Azimuthal anchoring transition of nematic liquid crystals on self-assembled monolayers formed from odd and evan alkanethiols,”Physical Review E,vol. 54, No. 5, pp. R4540-R4543, Nov. 1996; published by The American Physical Society.
Gupta, V. K., et al., “Uniform Anchoring of Nematic Liquid Crystals on Self-Assembled Monolayers Formed from Alkanethiols on Obliquely Deposited Films of Gold,”Langmuir,vol. 12, No. 10, pp. 2587-2593, 1996; published by American Chemical Society.
Yang, H. C., et al., “Molecular Interactions between Organized, Surface-Confined Monolayers and Vapor-Phase Probe Molecules. 8. Reactions between Acid-Terminated Self-Assembled Monolayers and Vapor-Phase Bases,”Langmuir,vol. 12, No. 3, pp. 726-735, 1996; published by American Chemical Society.
Wells., M., et al., “Interactions between Organized, Surface-Confined Monolayers and Vapor-Phase Probe Molecules. 9. Structure/Reactivity Relationship between Three Surface-Confined Isomers of Mercaptobenzoic Acid and Vapor-Phase Decylamine,”Langmuir,vol. 12, No. 8, pp. 1989-1996, 1996.
Crooks, R. M., “Interactions between self-assembled monolayers and an organosphosphonate,”Faraday Discuss.,vol. 107, pp. 285-305, 1997.
Delamarche, E., et al., “Patterned Delivery of Immunoglobulins to Surfaces Using Microfluidic Networks,”Science,vol. 276, pp. 779-781, May 2, 1997.
Jenkins, A. L., et al., “Polymer Based Lanthanide Luminescent Sensors for the Detection of Nerve Agents,”Anal. Comm.,vol. 34, pp. 221-224, Aug. 1997.
Gupta, V. K., et al., “Optical Amplification of Ligand-Receptor Binding Using Liquid Crystals,”Science,vol. 279, pp. 2077-2080, Mar. 27, 1998.
Ricco, A. J., et al., “Surface Acoustic Wave Chemical Sensor Arrays: New Chemically Sensitive Interfaces Combined with Novel Cluster Analysis To Detect Volatile Organic Compounds and Mixtures,”Acc. Chem. Res.,vol. 31, No. 5, pp. 289-296, 1998; published by American Chemical Society.
Crooks, R. M., et al., “New Organic Materials Suitable for Use in Chemical Sensor Arrays,”Acc. Chem. Res.,vol. 31, No. 5, pp. 219-227, 1998; published by American Chemical Society.
Swager, T. M., “The Molecular Wire Approach to Sensory Signal Amplification,”Acc. Chem. Res.,vol. 31, No. 5, pp. 201-207, 1998; published by American Chemical Society.
Shah, R. R., et al., Using Liquid Crystals To Image Reactants and Products of Acid-Base Reactions on Surfaces with Micrometer Resolution,J. Am. Chem. Soc.,vol. 121, No. 49, pp. 11300-11310, 1999; published by American Chemical Society.
Skaife, J. J., et al., “Quantitative Characterization of Obliquely Deposited Substrates of Gold by Atomic Force Microscopy: Influence of Substrate Topography on Anchoring of Liquid Crystals,”Chem. Mater.,vol. 11, No. 3, pp. 612-623, 1999; published by American Chemical Society.
Bertilsson, L., et al., “On the Adsorption of Dimethyl Methylphosphonate on Self-Assembled Alkanethiolate Monolayers: Influence of Humidity,”Langmuir,vol. 15, No. 4, pp. 1128-1135, 1999; published by American Chemical Society.
Jenkins, A. L., et al., “Polymer-Based Lanthanide Lumi

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