Trinitroglycerol sustained release vehicles and preparation ther

Details Trinitroglycerol sustained release vehicles and preparation ther Trinitroglycerol sustained release vehicles and preparation ther

1983-08-16

1985-09-17

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 22, 424 80, 514509, A61K 3121, A61K 3179, A61K 3174, A61L 1503

Patent

active

045420130

ABSTRACT:
A trinitroglycerol-containing substantially disaccharide-free polymeric diffusion matrix is provided for the transdermal systemic delivery of trinitroglycerol through the skin of a patient. The polymeric diffusion matrix contains sufficient trinitroglycerol to be released over a prolonged period of time and comprises a first lower molecular weight, partially hydrolyzed polyvinylalcohol component, a second higher molecular weight, essentially fully hydrolyzed polyvinylalcohol component, and glycerol.

REFERENCES:
patent: 4291015 (1981-09-01), Keith et al.

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