Protein and DNA thereof

Details Protein and DNA thereof Protein and DNA thereof

2006-12-05

2006-12-05

Monshipouri, Maryam (Department: 1653)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S320100, C435S006120, C536S023200

Reexamination Certificate

active

07144720

ABSTRACT:
The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.

REFERENCES:
patent: 5990293 (1999-11-01), Docherty et al.
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GENBANK Accession No. A61275, “Sequence 1 from Patent WO9709430,” (Mar. 1998).
Hite, et al., “Sequence of a cDNA clone encoding the zinc metalloprotease hemorrahgic toxin e from Crotalus atrox: Evidence for signal, zymogen and disintegrin-like structures,” Biochemistry 31:6203-6211 (1992).
Howard, et al., “Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types,” Biochem. J. 317:45-50 (1996).
Kratzschmar, et al., “Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence,” J. Biol. Chem. 271(9):4593-4596 (1996).
Paine, M.J.I. et al., “Cloning of metalloprotease genes in the carpet viper (Echis pyramidum leakeyi): Further members of the metalloprotease/disintegrin gene family,”Eur. J. Biochem. 224:483-488 (1994).
Wolfsberg, T.J. et al., “ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: Multipotential functions in cell-cell and cell-matrix interactions,”J. Cell Biol. 131:275-278 (1995).

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