Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Reexamination Certificate
2006-08-01
2006-08-01
Mosher, Mary E. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
C424S093100, C424S258100, C435S471000, C435S252300, C435S252800, C435S879000
Reexamination Certificate
active
07083794
ABSTRACT:
Attenuated immunogenic bacteria having an RpoS+phenotype, in particular,Salmonella entericaserotypeTyphihaving an RpoS+phenotype and methods therefor are disclosed. TheSalmonellahave in addition to an RpoS+phenotype, an inactivating mutation in one or more genes which render the microbe attenuated, and a recombinant gene capable of expressing a desired protein. TheSalmonellaare attenuated and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for genes and gene products. Also disclosed are methods for preparing the vaccine delivery vehicles.
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Curtiss III Roy
Nickerson Cheryl A.
Mosher Mary E.
Thompson & Coburn LLP
Washington University
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