Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se
Reexamination Certificate
2006-11-14
2006-11-14
Qian, Celine (Department: 1633)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Rodent cell, per se
C435S069100, C435S455000
Reexamination Certificate
active
07135338
ABSTRACT:
This invention comprises of construction of a recombinant CHO cell line that produces functional mannose binding lectin (MBL) and of special uses of MBL. Specially, use of MBL for development of a therapeutic agent for patients having systemic infection with viruses, bacteria, or fungus is described. More specifically, MBL as a trigger for complement activation and MBL so formulated to activate complement system for the purpose of treating patients with microbial infection.
REFERENCES:
patent: 6429192 (2002-08-01), Laursen
patent: WO 00/70043 (2000-11-01), None
patent: WO 02/14525 (2002-02-01), None
Vorup-Jensen et al. Recombinant expression of human mannan-binding lectin. International Immunopharmacology 1:677-687, 2001.
Ohtani et al. High-level and effective production of human mannan-binding lectin (MBL) in Chinese hamster ovary (CHO) cells. Journal of Immunological Methods 222:135-144, 1999.
Ma et al. Functional expression of human Mannan-binding proteins (MBPs) in human hepatoma cell lines infected with recombinant vaccinia virus. J. Biochem. 122:810-818, 1997.
Ahn Byung Cheol
Moon Hong Mo
Yum Jung-Sun
Dobeel Corporation
Gordon & Rees LLP
Nguyen Quang
Qian Celine
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