Methods and compositions for screening using diphtheria...

Details Methods and compositions for screening using diphtheria... Methods and compositions for screening using diphtheria...

2006-06-13

2006-06-13

Ponnaluri, Padmashri (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S005000, C435S320100, C435S069100, C435S069700, C435S091500, C536S023100, C536S024100

Reexamination Certificate

active

07060433

ABSTRACT:
The invention relates to methods and compositions utilizing diphtheria toxin for screening purposes. The invention is particularly useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.

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Grignani, F. et al. “High-Effciency Gene Transfer and Selection of Human Hematopoietic Progenitor Cells with a Hybrid EBV/Retroviral Vector Expressing the Green Fluorescence Protein” Cancer Research, vol. 58, pp. 14-19.
Fen et al., “Structural Organization and Chromosomal Assignment of the Gene Encoding the Human Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor,”Biochemistry32(31):7932-7938 (1993).
Grignani et al., “High Efficiency Gene Transfer and Selection of Human Humatopoietic Progenitor Cells with a Hybrid EBV/Retroviral Vector Expressing the Green Fluorescence Protein,”Cancer Research58:14-19 (Jan. 1998).
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Shields, R.L. et al., “Inhibition of Allergic Reactions with Antibodies to IgE,”Int Arch Allergy Immunol.107(1-3):308-312 (May-Jun. 1995).

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