Steroid cream formulation

Details Steroid cream formulation Steroid cream formulation

1987-11-13

1989-09-19

Sneed, H. M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514180, A61K 3156

Patent

active

048681695

ABSTRACT:
A steroid cream formulation which has enhanced physical and chemical stability is formed of (11.beta.,17.alpha.)-17-(ethylthio)-9.alpha.-fluoro-11.beta.-hydroxy-17-(m ethylthio)androsta-1,4-dien-3-one (tipredane), and a vehicle containing as major ingredients glyceryl monostearate having an acid value of greater than 4, propylene glycol and water together with a sodium citrate or potassium citrate buffer, a non-acidic long chain fatty acid wax to impart proper consistency, and sodium metabisulfite as an antioxidant, together with emulsifiers, skin conditioners, emollients, lubricants and other conventional cream formulation ingredients.

REFERENCES:
patent: 3178345 (1965-04-01), Schlagel
patent: 4361559 (1982-11-01), Varma
patent: 4542129 (1985-09-01), Orentreich

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