Preparation and use of mixed mode solid substrates for...

Details Preparation and use of mixed mode solid substrates for... Preparation and use of mixed mode solid substrates for...

2006-12-05

2006-12-05

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

C436S529000, C436S530000, C436S531000, C436S161000, C530S408000, C530S412000, C530S415000, C548S152000, C548S174000, C422S070000

Reexamination Certificate

active

07144743

ABSTRACT:
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.

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