Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1986-12-19
1989-09-19
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 89, 546 23, 540476, C07F 965, A61K 31675
Patent
active
048681644
ABSTRACT:
The present invention relates to novel compounds having nitrogen-containing, saturated bicyclic cyclopentane-fused rings which are geminally disubstituted with phosphonate groups. Most preferred compounds of the present invention have the general structure: ##STR1## The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
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Buckingham Kent W.
Ebetino Frank H.
McOsker Jocelyn E.
Graff IV Milton B.
Norwich Eaton Pharmaceuticals, Inc.
Rotman Alan L.
Suter David L.
Zerby Kim William
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