Compounds and methods for diagnosis and immunotherapy of...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

Reexamination Certificate

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C530S300000, C424S168100, C424S248100, C435S004000, C435S041000

Reexamination Certificate

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07087713

ABSTRACT:
Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or moreMycobacteriumproteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection ofMycobacteriuminfection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization againstMycobacteriuminfection.

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Sequence alignment for SEQ ID No:163 and Cirillo et al.
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Griffin et al, Trends in Microbiology, vol. 3, No. 11, Nov. 1995.
Sequence alignment forCorynebacterium glutamicum.
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Kozak et al, Microbiological Review, Mar. 1983, p. 1-45.
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Griffin et al, Trends in Microbiology, vol. 3, No. 11, Nov. 1995.

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