Methods for treating solid tumors using neutron therapy

Details Methods for treating solid tumors using neutron therapy Methods for treating solid tumors using neutron therapy

2006-02-14

2006-02-14

Lacyk, John P. (Department: 3736)

Surgery

Radioactive substance applied to body for therapy

Radioactive substance placed within body

Reexamination Certificate

active

06997861

ABSTRACT:
The invention described herein comprises a method of treating a subject having a disorder characterized by the presence of one or more tumors comprising inserting a miniaturized concentrated neutron emitting source into said tumor(s) for a time sufficient to irradiate the cells of the tumor(s). The invention method can be employed in the treatment of both malignant and non-malignant tumors and is especially useful in the treatment of malignant tumors found in the brain, prostate, and other internal organs. A preferred neutron source is californium-252. The majority of the tumor can be surgically removed prior to insertion of the neutron emitting source. In a further embodiment of the invention, a neutron capture compound can be localized to the cells of the tumor prior to insertion of the miniaturized neutron emitting source in order to augment the effects of neutron therapy.

REFERENCES:
patent: 6319189 (2001-11-01), Halpern et al.
patent: 6551232 (2003-04-01), Rivard
patent: 6685619 (2004-02-01), Halpern et al.
Yosh Maruyama et al., “Work in Progress: 252CF Neutron Brachytherapy for Hemispheric Malignant Giloma”, Radiology, vol. 145, No. 1, pp. 171-174, 1982.
J.G. Wierzbicki et al., “Measurement of Augmentation of 252CF implant by 10B and 157 Gd Neutron Capture”, Med. Phys., 21 (6), pp. 787-790, Jun. 1994.
Barthelemy et al., “The Development of Californium-252 Sealed Sources at the Commissariat A L'Energie Atomique”, Nuclear Technology, vol. 26, No. 2, pp. 201-214, 1975.

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