Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Reexamination Certificate
2006-06-06
2006-06-06
Zucker, Paul A. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
C554S124000
Reexamination Certificate
active
07057058
ABSTRACT:
A process for the preparation of 13-cis-retinoic acid (I)from 3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl)-triphenylphosphonium chloride (IIa)and 5-hydroxy-4-methyl-2(5H)-furanone (III)is herein disclosed. Compounds (IIa) and (III) are reacted in ethanol as the solvent and KOH as the base at a temperature ranging from −5 to 0° C. to give a mixture of retinoic acids which is isomerized to (I) by treatment with a palladium complex.
REFERENCES:
patent: 4556518 (1985-12-01), Lucci
Aspari Patrizio
Braglia Enrico
Braglia Riccardo
Mossi Waldo
Helsinn Advanced Synthesis SA
Zucker Paul A.
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