Human phosphatidic acid phosphatase

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

Reexamination Certificate

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C435S196000, C435S041000, C435S128000, C435S135000, C435S147000, C435S262000, C536S023200

Reexamination Certificate

active

07135314

ABSTRACT:
This invention relates to a biotechnology invention concerning human phosphatidic acid phosphatase. More particularly, this invention relates to three variants of human phosphatidic acid phosphatase namely PAP-α(1 and 2), PAP-β and PAP-γ and uses thereof.

REFERENCES:
E. Boder et al., “Identification of Type-2 Phosphatidic Acid Phosphohydrolase (PAPH-2) in Neutrophil Plasma Membranes”, Cellular Signalling 6(8): 933-941, 1994.
GENBANK entry U79294, Jan. 1997.
GENBANK entry AA040858, Aug. 1996.
GENBANK entry W04968, Apr. 1996.
GENBANK entry H68363, Oct. 1995.
Brindley, D.N. et al., “Phosphatidate phosphohydrolase and signal transduction,”Chemistry and Physics of Lipids, vol. 80, pp. 45-57 (1996).
Kent, C., “Eukaryotic Phospholipid Biosynthesis,”Annu. Rev. Biochem, vol. 64, pp. 316-343 (1995).
Abraham, E. et al., “Phosphatidic Acid Signaling Mediates Lung Cytokine Expression and Lung Inflammatory Injury After Hemorrhage in Mice,”J. Exp. Med., vol. 181, pp. 569-575 (1995).
Dillon, D.A. et al., “TheEscherichia colipgpB Gene Encodes for a Diacylglycerol Pyrophosphate Phosphatase Activity,”J. Biol. Chem., vol. 271, No. 48, pp. 30548-30553 (1996).
Rice, G.C. et al., “Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid,”Proc. Natl. Acad. Sci. USA, vol. 91, pp. 3857-3861 (1994).
Bursten, S. et al., “Potential Role for Phosphatidic Acid in Mediating the Inflammatory Responses to TNFα and IL-1β,”Circulatory Shock, vol. 44, pp. 14-29 (1994).
Kai, M. et al., “Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes,”J. Biol. Chem., vol. 271, No. 31, pp. 18931-18938 (1996).
Leung, D.W. et al., “CT-2576, an inhibitor of phospholipid signaling, suppresses constitutive and induced expression of human immunodeficiency virus,”Proc. Natl. Acad. Sci. USA, vol. 92, pp. 4813-4817 (1995).
Barila, D. et al., “The Dri 42 Gene, Whose Expression Is Up-regulated during Epithelial Differentiation, Encodes a Novel Endoplasmic Reticulum Resident Transmembrane Protein,”J. Biol. Chem., vol. 271, No. 47, pp. 29928-29936 (1996).
Shen, H. et al., “The CDS1 Gene Encoding CDP-diacylglycerol Synthase InSaccharomyces cerevisiaeIs Essential for Cell Growth,”J. Biol. Chem., vol. 271, No. 2, pp. 789-795 (1996).
English, D. et al., “Messenger functions of phosphatidic acid,”Chemistry and Physics of Lipids, vol. 80, pp. 117-132 (1996).
Levitzki, A., “Targeting signal transduction for disease therapy,”Current Opinion on Cell Biology, vol. 8, pp. 239-244 (1996).
GenBank human cDNA clone N75714, Jan. 1997.
GenBank human cDNA clone W70040, Oct. 1996.
GenBank human cDNA clone H17855, Jun. 1995.

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