Humanized antibody specific for surface antigen pre-S1 of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S130100, C424S133100, C530S387100, C530S387300

Reexamination Certificate

active

07115723

ABSTRACT:
The present invention relates to humanized antibodies specific for HBV surface antigen pre-S1, which show binding affinity similar to mouse monoclonal antibody and which show remarkably reduced immunogenicity since they have less mouse-derived amino acid residues. Thus, the humanized antibodies of the present invention may be useful for the prevention of HBV infection and for the treatment of hepatitis B.

REFERENCES:
patent: WO 93/16192 (1993-08-01), None
C.J. Ryu et al., “A Humanized Antibody with Specificity for Hepatitis B Surface Antigen”,Hum. Antibod. Hybridomas, vol. 7, No. 3, 1996, pp. 113-122.
C.J. Ryu et al., “In Vitro Neuralization of Hepatitis B Virus by Monoclonal Antibodies Against the Viral Surface Antigen”,Journal of Medical Virology, vol. 52, 1997, pp. 226-233.
Neurath and Kent, “The pre-S Region of Hepadnavirus Envelope Proteins”,Adv. Virus Res., vol. 34, 1998, pp. 65-142.
Iwarson, et al., “Neutralization of Hepatitis B Virus Infectivity by a Murine Monoclonal Antibody: An Experimental Study in the Chimpanzee”J. Med. Virol., vol. 16, 1985, pp. 89-96.
Itoh et al., “A Synthetic Peptide Vaccine Involving the Product of the Pre-S(2) Region of Hepatitis B Virus DNA: Protective Efficacy in Chimpanzees”,Proc. Natl. Acad. Sci., USA, vol. 83, 1986, pp. 9174-9178.
Budkowska et al., “Monoclonol Antibody Recognizing Pre-S(2) Epitope of Hepatitis B Virus: Characterization of Pre-S(2) Epitope and Anti-Pre-S(2) Antibody”,J. Med. Virol., vol. 20, 1986, pp. 111-125.
Milich et al., “Distinct H-2-linked Regulation of T-cell Responses to the pre-S and S Regions of the Same Hepatitis B Surface Antigen Polypeptide Allows Circumvention of Nonresponsiveness to the S Region”, Proc.Natl. Acad. Sci., USA, vol. 82, 1985, pp. 8168-8172.
Milich et al., “Immune Response to the Pre-S(1) Region of the Hepatitis B Surface Antigen (HbsAg): A Pre-S(1)-Specific T Cell Response can Bypass Nonresponsiveness to the Pre-S(2) and S Regions of HBsAg1”,J. Immunol, vol. 137, 1986, pp. 315-322.
Heermann et al., “Large Surface Proteins of Hepatitis B Virus Containing the Pre-s Sequence”,J. Virol, vol. 52, No. 2, 1984, pp. 396-402.
Neurath et al., “Identification and Chemical Synthesis of a Host Cell Receptor Binding Site on Hepatitis B Virus”,Cell, vol. 46, 1986, pp. 429-436.
Pontisso et al., “Identification of an Attachment Site for Human Liver Plasma Membranes on Hepatitis B Virus Particles”,Virology, vol. 173, 1989, pp. 522-530.
Neurath et al., “Antibodies to Synthetic Peptides from the Pre-S1 Region of the Hepatitis B Virus (HBV) Envelope (env) Protein are Virus-neutralizing and Protective”,Vaccine, vol. 7, 1989, pp. 234-236.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Humanized antibody specific for surface antigen pre-S1 of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Humanized antibody specific for surface antigen pre-S1 of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Humanized antibody specific for surface antigen pre-S1 of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3684430

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.